Statistically, cancer is likely to affect almost all of us in some way, either directly or through someone we know. Luke Ryan’s A Funny Thing Happened on the Way to Chemo, now also a published book, presents a warm and witty perspective of the disease, based on Ryan’s own experiences. Diagnosed with cancer at 11 and again at 22, Ryan (now aged 30) describes his ordeal without romanticising it, and with an honest sense of humour.

It’s unusual subject matter for a stand-up comedy show, but that means that there’s an abundance of original material. Ryan manages to find the funny side of baldness, vomiting and other unpleasant parts of his cancer saga. At no point does the show become too morbid, as Ryan focuses on his everyday challenges, decisions and relationships rather than delving into deep philosophical questions of life and death.

Although the primary drawcard of the show is its focus on cancer, Ryan includes quite a few anecdotes unrelated to illness. He also makes several passing comments indicating his intention to move beyond the subject in the future. With a flair for storytelling and a genuine connection with his audience, Ryan’s comic talent doesn’t come across as too reliant on novelty, if you could call a brush with cancer ‘novel’.

There are moments that induce winces of sympathy and others uproarious laughter. Ryan has a casual charm that makes him seem like someone you would meet at a party, but a captivating story that will inspire you to always seek out the humour in misfortune.

A Funny Thing Happened on the Way to Chemo is on from 18-20 and 22-25 September at The Ballroom, Lithuanian Club: North Melbourne, 7pm on Sunday and 8pm all other nights. Book tickets at melbournefringe.com.au or call (03) 9660 9666.